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J Natl Cancer Inst. 1975 Apr;54(4):985-8.

Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants.


A phytochemical investigation to identify inducers of increased aryl hydrocarbon hydroxylase (AHH) activity from three cruciferous vegetables, Brussels sprouts, cabbage, and cauliflower, resulted in the identification of indole-3-acetonitrile, indole-3-carbinol, and 3,3'-diindolylmethane as naturally occurring inducers. These compounds are produced during the hydrolysis of indolyl-methyl glucosinolate by the plant enzyme myrosinase.

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