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Nat Immunol. 2001 Apr;2(4):316-24.

Gene regulation mediated by calcium signals in T lymphocytes.

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Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

Erratum in

  • Nat Immunol. 2008 Mar;9(3):328-9.


Modulation of many signaling pathways in antigen-stimulated T and B cells results in global changes in gene expression. Here we investigate the contribution of calcium signaling to gene expression in T cells using cell lines from two severe-combined immunodeficiency patients with several cytokine deficiencies and diminished activation of the transcription factor NFAT nuclear factor of activated T cells. These T cells show a strong defect in transmembrane calcium influx that is also apparent in their B cells and fibroblasts. DNA microarray analysis of calcium entry-deficient and control T cells shows that Ca2+ signals both activate and repress gene expression and are largely transduced through the phosphatase calcineurin. We demonstrate an elaborate network of signaling pathways downstream of the T cell receptor, explaining the complexity of changes in gene expression during T cell activation.

[Indexed for MEDLINE]

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