Format

Send to

Choose Destination
Obstet Gynecol. 2001 Apr;97(4):485-90.

Antenatal dexamethasone and decreased birth weight.

Author information

1
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. steven.bloom@email.swmed.edu

Abstract

OBJECTIVE:

To test the hypothesis that antenatal dexamethasone treatment to promote fetal lung maturation results in decreased birth weight corrected for gestational age.

METHODS:

The birth weights of all dexamethasone-treated, singleton, live-born infants delivered at our hospital were compared with our overall obstetric population; a group of untreated infants frequency matched approximately 3:1 according to maternal race, infant sex, and gestational age at delivery; and an historical cohort of infants with an indication for dexamethasone but delivered in the 12 months before the introduction of corticosteroid therapy at our hospital.

RESULTS:

Dexamethasone-treated infants (n = 961), when compared with either the overall population (n = 122,629) or matched controls (n = 2808), had significantly lower birth weights after adjustment for week of gestation (P <.001). Compared with the historical cohort of infants, the average birth weight of dexamethasone-treated infants was smaller by 12 g at 24-26 weeks, 63 g at 27-29 weeks, 161 g at 30-32 weeks, and 80 g at 33-34 weeks' gestation.

CONCLUSION:

Antenatal dexamethasone administered to promote fetal maturation is associated with diminished birth weight.

PMID:
11275014
DOI:
10.1016/s0029-7844(00)01206-0
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center