Format

Send to

Choose Destination
Trends Immunol. 2001 Apr;22(4):205-11.

IgA and the IgA Fc receptor.

Author information

1
Departments of Cell Biology and Immunology and Surgical Oncology, Vrije Universiteit, Van de Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.

Abstract

IgA has traditionally been regarded a non-inflammatory antibody. This might indeed be true for secretory IgA (SIgA), which exerts its function at mucosal surfaces where commensal microorganisms and dietary antigens prevail. Serum IgA, however, potently triggers (pro)-inflammatory activity upon binding to the myeloid IgA receptor, FcalphaRI. Here, new insights in the roles of IgA and FcalphaRI are addressed and a model integrating the various functions of IgA in immunity is discussed.

Comment in

PMID:
11274926
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center