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Carcinogenesis. 1980;1(12):989-94.

Malignant transformation by the DNA-protein crosslinking agent trans-Pt(II) diamminedichloride.

Author information

1
Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

Trans-Pt(II) diamminedichloride (trans-Pt) produced high levels of DNA-protein crosslinks in mouse C3H-10T1/2 cells and mouse 3T3 cells. Trans-Pt induced malignant transformation in these cell types at all doses tested. In 10T1/2 cells trans-Pt induced moderate levels of transformation similar to that induced by equitoxic doses of X-rays. Trans-Pt did not act as a tumor promoter and enhance the transformation frequency seen with X-rays when cells were irradiated and then treated with this agent.

PMID:
11272115
DOI:
10.1093/carcin/1.12.989
[Indexed for MEDLINE]

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