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Acta Neuropathol. 2001 Feb;101(2):154-8.

Up-regulation of cyclooxygenase-2 in inflammatory demyelinating neuropathy.

Author information

1
Department of Neurology, Graduate School of Medicine, Kyoto University, Japan.

Abstract

To clarify the role of prostaglandins in peripheral nerve demyelination, we examined the expression of cyclooxygenase-2 (COX-2) using selected nerve specimens from patients with chronic inflammatory demyelinating polyneuropathy. COX-2 protein was up-regulated in macrophages causing active demyelination. In situ hybridization revealed that COX-2 mRNA signals were strongly expressed on macrophages adhering to the demyelinating nerve fibers at the endoneurium. This observation may provide a rationale for application of neuroprotective strategies employing COX-2 inhibitors in inflammatory demyelinating neuropathies.

PMID:
11271370
DOI:
10.1007/s004010000279
[Indexed for MEDLINE]

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