Format

Send to

Choose Destination
Drug Metab Rev. 2001 Feb;33(1):1-35.

Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons.

Author information

1
Department of Veterinary Physiology and Pharmacology & Center for Environmental and Rural Health, Texas A&M University, College Station, USA.

Abstract

Polycyclic aromatic hydrocarbons are ubiquitous contaminants in the environment. Benzo[a]pyrene (BaP), a prototypical member of this class of chemicals, has been extensively studied for its toxic effects in laboratory animals and human populations. BaP toxicity is often mediated by oxidative metabolism to reactive intermediates that interact with macromolecules leading to alterations in target cell structure and function. More recent evidence suggests that disruption of cellular signaling pathways involved in the regulation of growth and differentiation contribute significantly to the toxicity of BaP and its metabolites. This review summarizes recent advances in our understanding of biological mechanisms of BaP toxicity at the molecular level, and the role of metabolic intermediates in carcinogenesis, atherogenesis, and teratogenesis.

PMID:
11270659
DOI:
10.1081/dmr-100000138
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center