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EMBO Rep. 2000 Oct;1(4):313-8.

Chunnel vision. Export and efflux through bacterial channel-tunnels.

Author information

1
University of Cambridge Department of Pathology, UK.

Abstract

The Escherichia coli TolC protein is central to toxin export and drug efflux across the inner and outer cell membranes and the intervening periplasmic space. The crystal structure has revealed that TolC assembles into a remarkable alpha-helical trans-periplasmic cylinder (tunnel) embedded in the outer membrane by a contiguous beta-barrel (channel), so providing a large duct open to the outside environment. The channel-tunnel structure is conserved in TolC homologues throughout Gram-negative bacteria, and it is envisaged that they are recruited and opened, through a common mechanism, by substrate-specific inner-membrane complexes.

PMID:
11269495
PMCID:
PMC1083749
DOI:
10.1093/embo-reports/kvd075
[Indexed for MEDLINE]
Free PMC Article

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