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Aten Primaria. 2000 Oct 31;26(7):468-71.

[Seasonal change in blood concentration of uric acid and its potential clinical implications].

[Article in Spanish]

Author information

1
Centro de Atención Primaria Pintor Stolz, 35, 46018 Valencia. cspstolzmg@meditex.es

Abstract

OBJECTIVE:

To determine whether uric acid in plasma of patients registered at a PCC varies with the season.

DESIGN:

Descriptive study, with two transversal cuts, one in winter and one in summer.

SETTING:

Health district on the outskirts of Valencia.

PATIENTS:

Selected at random from all patients over 18 with medical records, with appointments in January-February and July-August 1999. Sample size was calculated for paired data with an alpha error of 0.05 and beta error of 20%. The pertinent level of uraemia was set at 0.4 mg/dl. Variability was deduced from a mini-sample of 17 cases in a sample of 72 patients. The following were recorded: sex, age, BMI, blood count, glucaemia, total cholesterol, HDL-c, LDL-c, uric acid and triglycerides. Meteorological data were supplied by the Valencia Weather Centre.

MEASUREMENTS AND MAIN RESULTS:

Temperature (12.8 degrees C versus 25.8 degrees C), sun (9.9 hours a day versus 5.9) and relative humidity (67.1% versus 61.4%) were greater in summer than in winter. There were no differences in mean atmospheric pressure (760.1 mmHg versus 760.7). 75 patients with a mean age of 63 finished the study. Mean uric acid was higher in summer at 5.64 mg/dl (95% CI, 5.29-5.99) than in winter at 5.23 mg/dl (CI, 4.92-5.56). We found no significant differences in the BMI, red corpuscles, haematocrits, glucaemia, total or divided cholesterol, or triglycerides.

CONCLUSION:

Seasonal variation in the plasma concentration of uric acid was found in the sample studied.

PMID:
11268547
DOI:
10.1016/s0212-6567(00)78705-1
[Indexed for MEDLINE]
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