Format

Send to

Choose Destination
See comment in PubMed Commons below
Anticancer Res. 2000 Sep-Oct;20(5C):3785-90.

Cryosurgery as a means to improve surgical treatment of patients with multiple unresectable liver metastases.

Author information

1
Department of Surgery, Centre Léon Bérard, 28, Rue Laënnec, 69373 Lyon, France. rivoire@lyon.fnclcc.fr

Abstract

BACKGROUND:

The aim of the study was to evaluate the results of cryosurgery in patients with multiple (five or more), heavily pretreated, unresectable liver metastases.

MATERIALS AND METHODS:

Nineteen patients with multiple unresectable liver metastases were entered into a prospective nonrandomized trial. The liver tumours were treated during surgery under ultrasound guidance. All the patients were followed-up to assess complications, treatment response and sites of recurrence.

RESULTS:

140 metastases were identified in 19 patients (mean, 7; range, 5-25) and 13 patients had a synchronous liver resection. Cryosurgery was used to treat 90 metastases (mean diameter, 30 mm; range, 10-135). There were no treatment-related deaths and the overall rate of complications was 21%. During a mean follow-up of 28 months (range, 5-60), tumours recurred at the site of cryosurgery in two patients (10%), in the remaining liver in nine patients (47%) and elsewhere in five patients (26%). Three patients had no evidence of disease 48, 50 and 60 months after liver cryosurgery, respectively.

CONCLUSION:

Cryosurgery may be effective in the treatment of patients with multiple unresectable liver metastases and should be investigated in multimodality treatment programmes.

PMID:
11268455
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center