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Phytother Res. 2001 Mar;15(2):172-3.

Garcinia extract inhibits lipid droplet accumulation without affecting adipose conversion in 3T3-L1 cells.

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Department of Food and Nutrition, Nagoya Bunri College, 2-1 Sasazuka-cho, Nishi-ku, Nagoya 451-0077, Japan.


Garcinia extract was isolated from the fruit of the Garcinia cambogia and was used as a potential antiobesity agent. In week 3 of culture with insulin, the fat cells exhibited more numerous and larger intracytoplasmic lipid droplets (i.e. 30-40 microm(2)). When Garcinia extract and insulin were added simultaneously, the accumulation of lipid droplets was inhibited and the peak droplet area shifted to become smaller (10-20 microm(2)). The activities of glycerophosphate dehydrogenase, a marker of adipose differentiation, were not significantly inhibited by the Garcinia extract. These findings suggest that the Garcinia extract inhibits lipid droplet accumulation in fat cells without affecting adipose conversion.

[Indexed for MEDLINE]

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