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J Emerg Med. 2001 Apr;20(3):267-72.

Metformin-associated lactic acidosis.

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Detroit Receiving Hospital and Wayne State University School of Medicine, Detroit, Michigan 48201, USA.


In 1995, the oral antihyperglycemic agent, metformin, was introduced in the United States for treating diabetes mellitus. Rare cases of metformin-associated lactic acidosis caused by the accumulation of the drug in patients with renal dysfunction have been described, although a detailed time course of the resulting metabolic derangements has not been reported. A case of metformin-associated lactic acidosis is presented along with key serial laboratory abnormalities observed during the treatment phase. The patient made a complete recovery following therapy with hemodialysis and supportive care.

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