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Eur J Obstet Gynecol Reprod Biol. 2001 Mar;95(1):46-51.

The effect of 17beta-estradiol on isolated omental arteries from preeclamptic women.

Author information

1
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA. yvedernikov@utmb.edu

Abstract

OBJECTIVE:

To study the effect of 17beta-estradiol on isolated omental arteries from preeclamptic women.

STUDY DESIGN:

Rings of omental artery with intact endothelium were mounted in organ chambers for isometric tension recording. We studied the effect of pharmacological concentrations of 17beta-estradiol on potassium chloride-induced tension and the concentration-contraction relationships for norepinephrine and calcium.

RESULTS:

Cumulative application of 17beta-estradiol, in a concentration-dependent manner, relaxed potassium chloride contracted rings. Sixty minutes of incubation with 17beta-estradiol (10(-5)mol/l) attenuated the tension developed in response to potassium chloride, norepinephrine and calcium. Tamoxifen (10(-6)mol/l) did not antagonize the inhibitory actions of 17beta-estradiol.

CONCLUSIONS:

Pharmacological concentrations of 17beta-estradiol retain the capability for relaxing omental artery rings from preeclamptic women. The loss of refractoriness to norepinephrine, increased responsiveness to calcium ions and decreased ability of 17beta-estradiol to inhibit calcium-induced tension may be responsible for increased vascular reactivity in preeclampsia.

PMID:
11267719
DOI:
10.1016/s0301-2115(00)00359-6
[Indexed for MEDLINE]

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