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Protein Sci. 2001 Feb;10(2):455-8.

MPtopo: A database of membrane protein topology.

Author information

1
Department of Physiology and Biophysics, University of California, Irvine, California 92697-4560, USA.

Abstract

The reliability of the transmembrane (TM) sequence assignments for membrane proteins (MPs) in standard sequence databases is uncertain because the vast majority are based on hydropathy plots. A database of MPs with dependable assignments is necessary for developing new computational tools for the prediction of MP structure. We have therefore created MPtopo, a database of MPs whose topologies have been verified experimentally by means of crystallography, gene fusion, and other methods. Tests using MPtopo strongly validated four existing MP topology-prediction algorithms. MPtopo is freely available over the internet and can be queried by means of an SQL-based search engine.

PMID:
11266632
PMCID:
PMC2373945
DOI:
10.1110/ps.43501
[Indexed for MEDLINE]
Free PMC Article

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