Format

Send to

Choose Destination
Emerg Infect Dis. 2001 Jan-Feb;7(1):43-8.

Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.

Author information

1
Laboratoire des Yersinia, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France.

Abstract

Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997. We describe a second Y. pestis strain with high-level resistance to streptomycin, isolated from a human case of bubonic plague in Madagascar. The resistance determinants were carried by a self-transferable plasmid that could conjugate at high frequencies to other Y. pestis isolates. The plasmid and the host bacterium were different from those previously associated with multiple-drug resistance, indicating that acquisition of resistance plasmids is occurring in this bacterial species. Emergence of resistance to streptomycin in Y. pestis represents a critical public health problem since this antibiotic is used as the first-line treatment against plague in many countries.

PMID:
11266293
PMCID:
PMC2631670
DOI:
10.3201/eid0701.010106
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC-NCEZID Icon for PubMed Central
Loading ...
Support Center