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Bioorg Med Chem Lett. 2001 Mar 12;11(5):733-6.

The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa.

Author information

1
Prosthetics Molecular Design, Beechfield House, Macclesfield, UK. stuart.jones@protherics.com

Abstract

Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa.

PMID:
11266180
DOI:
10.1016/s0960-894x(01)00042-7
[Indexed for MEDLINE]

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