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Bioorg Med Chem Lett. 2001 Mar 12;11(5):705-9.

Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.

Author information

1
Novartis Institute for Medical Sciences, London, UK. ed.dziadulewicz@pharma.novartis.com

Abstract

A beta-turn overlay hypothesis has been used to transform the core scaffold of a selective non-peptide bradykinin B2 receptor antagonist into ligands specifically recognized by the CCK2 or NK1 receptors.

PMID:
11266174
DOI:
10.1016/s0960-894x(01)00044-0
[Indexed for MEDLINE]

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