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Bioorg Med Chem Lett. 2001 Mar 12;11(5):641-5.

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

Author information

1
DuPont Pharmaceuticals Company, Wilmington, DE 19880-0500, USA. john.m.fevig@dupontpharma.com

Abstract

The selective inhibition of coagulation factor Xa has emerged as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe highly potent benzamidine factor Xa inhibitors based on a vicinally-substituted heterocyclic core.

PMID:
11266160
DOI:
10.1016/s0960-894x(01)00029-4
[Indexed for MEDLINE]

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