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EMBO Rep. 2000 Aug;1(2):122-6.

Mini- and microsatellite expansions: the recombination connection.

Author information

1
Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, Paris, France. gfrichar@pasteur.fr

Abstract

It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility that it may also be responsible for trinucleotide repeat expansions. We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders.

PMID:
11265750
PMCID:
PMC1084263
DOI:
10.1093/embo-reports/kvd031
[Indexed for MEDLINE]
Free PMC Article

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