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Nat Rev Mol Cell Biol. 2001 Mar;2(3):202-10.

SUMO, ubiquitin's mysterious cousin.

Author information

1
Max Planck Institute of Biochemistry, Department of Molecular Cell Biology, Am Klopferspitz 18a, 82152, Martinsried, Germany. stmuelle@biochem.mpg.de

Abstract

Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates various cellular processes, such as nuclear transport, signal transduction, stress response and cell-cycle progression. But, in contrast to ubiquitylation, sumoylation does not tag proteins for degradation, but seems to enhance their stability or modulate their subcellular compartmentalization.

PMID:
11265250
DOI:
10.1038/35056591
[Indexed for MEDLINE]

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