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Interactions between monoamines, glutamate, and GABA in schizophrenia: new evidence.

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1
Institute of Physiology and Pharmacology, University of Göteborg, Göteborg, Sweden. arvid.carlsson@pharm.gu.se

Abstract

In spite of its proven heuristic value, the dopamine hypothesis of schizophrenia is now yielding to a multifactorial view, in which the other monoamines as well as glutamate and GABA are included, with a focus on neurotransmitter interactions in complex neurocircuits. The primary lesion(s) in schizophrenia does not necessarily involve any of these neurotransmitters directly but could deal with a more general defect, such as a faulty connectivity of developmental origin. Nevertheless, a precise identification of neurotransmitter aberrations in schizophrenia will probably provide clues for a better understanding of the disease and for the development of new treatment and prevention strategies.

[Indexed for MEDLINE]

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