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J Virol. 2001 Apr;75(8):3988-92.

Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles.

Author information

  • 1Laboratory of Molecular Retrovirology, Clinical Services Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA. timamichi@nih.gov

Abstract

The potential roles of an amino acid deletion at codon 67 (Delta67) and a Thr-to-Gly change at codon 69 (T69G) in the reverse transcriptase of human immunodeficiency virus (HIV) type 1 in drug sensitivity and relative replication fitness were studied. Our results suggest that the Delta67 and T69G changes can be categorized as mutations associated with multidrug resistance. The combination of both mutations with an L74I change (Delta67+T69G/L74I) leads to a novel 3'-azido-3'-deoxythymidine resistance motif and compensates for impaired HIV replication.

PMID:
11264389
PMCID:
PMC114891
DOI:
10.1128/JVI.75.8.3988-3992.2001
[PubMed - indexed for MEDLINE]
Free PMC Article
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