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Br J Ophthalmol. 2001 Apr;85(4):471-3.

Suspension of anticytomegalovirus maintenance therapy following immune recovery due to highly active antiretroviral therapy.

Abstract

AIM:

To describe the authors' experience with discontinuation of anti-cytomegalovirus (CMV) maintenance therapy in patients showing immune recovery following highly active antiretroviral therapy (HAART).

METHODS:

Retrospective analysis of the records of 41 patients who presented with CMV retinitis and whose maintenance therapy was discontinued from March 1997 to December 1999.

RESULTS:

41 patients had their anti-CMV therapy discontinued. The mean follow up after discontinuation of maintenance therapy in April 2000 was 20.4 months. At the time of discontinuation of maintenance therapy the lowest CD4+ count was 143 cells x 10(6)/l and only three patients had detectable HIV viral load. No reactivation or progression was seen in any of these patients after suspension of maintenance therapy.

CONCLUSION:

The anti-CMV maintenance therapy could be discontinued safely in patients with CD4+ above 150 cells x 10(6)/l although close follow up remains necessary especially in patients whose CD4+ count drops below this level.

PMID:
11264139
PMCID:
PMC1723929
[Indexed for MEDLINE]
Free PMC Article
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