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Histopathology. 2001 Mar;38(3):221-4.

Apocrine adenosis of the breast: clonal evidence of neoplasia.

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1
Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan. yendo@med.id.yamagata-u.ac.jp

Abstract

AIMS:

We report here a case of apocrine adenosis of the breast in a 66-year-old woman. To clarify the nature of this lesion, we examined it by clonal analysis.

METHODS AND RESULTS:

The lesion, 43 mm at its greatest dimension, was ill-circumscribed, lacking a fibrous capsule, and was composed of compact glands that showed typical histological features of apocrine adenosis. Clonality analysis, using the polymerase chain reaction (PCR)-based method for females heterozygous for a BstXI polymorphism of the X-linked phosphoglycerokinase (PGK) gene, revealed the monoclonal nature of the lesion.

CONCLUSIONS:

This result strongly suggests that some populations of apocrine adenosis are already neoplastic, and this could contribute to the premalignant potential of this lesion.

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PMID:
11260302
[Indexed for MEDLINE]
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