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Br J Clin Pharmacol. 2001 Feb;51(2):143-6.

Disposition and metabolism of the flavonoid chrysin in normal volunteers.

Author information

1
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Division of Clinical Pharmacology, Medical University of South Carolina, Charleston, SC 29425, USA. wallet@musc.edu

Abstract

AIMS:

To describe the oral disposition of the dietary flavonoid chrysin in healthy volunteers.

METHODS:

Oral 400 mg doses of chrysin were administered to seven subjects. Chrysin and metabolites were assayed in plasma, urine and faeces by h.p.l.c.

RESULTS:

Peak plasma chrysin concentrations were only 3-16 ng ml(-1) with AUCs of 5-193 ng ml(-1) h. Plasma chrysin sulphate concentrations were 30-fold higher (AUC 450-4220 ng ml(-1) h). In urine, chrysin and chrysin glucuronide accounted for 0.2-3.1 mg and 2-26 mg, respectively. Most of the dose appeared in faeces as chrysin. Parallel experiments in rats showed high bile concentrations of chrysin conjugates.

CONCLUSIONS:

These findings, together with previous data using Caco-2 cells, suggest that chrysin has low oral bioavailability, mainly due to extensive metabolism and efflux of metabolites back into the intestine for hydrolysis and faecal elimination.

PMID:
11259985
PMCID:
PMC2014445
[Indexed for MEDLINE]
Free PMC Article

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