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Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):125-48.

Responsive polymeric delivery systems.

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Department of Chemical Engineering, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel.


This paper discusses the state of the art in a relatively new approach in the field of controlled drug delivery-responsive polymeric drug delivery systems. Such systems are capable of adjusting drug release rates in response to a physiological need. The fundamental principles of externally and self-regulated delivery systems are examined. Special attention is paid to specific clinical settings such as diabetes, presenting the advantages and disadvantages of different approaches.

[Indexed for MEDLINE]

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