Format

Send to

Choose Destination
Pharmacogenomics. 2000 Feb;1(1):15-26.

The predictive power of haplotypes in clinical response.

Author information

1
Genaissance Pharmaceuticals, New Haven, CT 06511, USA. r.judson@genaissance.com

Abstract

A variety of approaches have been proposed to find genetic markers that can be used in a clinical setting. Single nucleotide polymorphisms (SNPs) are the basis of the most commonly used approaches. Here we describe an approach using gene-based haplotypes, which are collections of SNPs located throughout the ftinctional regions of candidate genes, and organised as they occur separately on an individual's two chromosomes. The main point of this review is that the haplotype has greater power than any individual SNP to track an unobsenrved, but evolutionarily linked, variable site.

PMID:
11258593
DOI:
10.1517/14622416.1.1.15
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center