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FEBS Lett. 2001 Mar 16;492(3):193-8.

The TIM-barrel fold: a versatile framework for efficient enzymes.

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  • 1Biocenter Oulu and Department of Biochemistry, University of Oulu, Linnanmaa, Oulu, Finland.


Recent studies on triosephosphate isomerase (TIM)-barrel enzymes highlight the remarkable versatility of the TIM-barrel scaffold. At least 15 distinct enzyme families use this framework to generate the appropriate active site geometry, always at the C-terminal end of the eight parallel beta-strands of the barrel. Sequence and structure comparisons now suggest that many of the TIM-barrel enzymes are evolutionarily related. Common structural properties of TIM-barrel enzymes are discussed.

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