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Cell Signal. 2001 Feb;13(2):73-83.

Receptor activity modifying proteins.

Author information

1
Molecular Pharmacology Laboratory, Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia. p.sexton@hfi.unimelb.edu.au

Abstract

Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.

PMID:
11257451
DOI:
10.1016/s0898-6568(00)00143-1
[Indexed for MEDLINE]

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