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Antimicrob Agents Chemother. 2001 Apr;45(4):1292-4.

Combination effect of vancomycin and beta-lactams against a Staphylococcus aureus strain, Mu3, with heterogeneous resistance to vancomycin.

Author information

1
Department of Bacteriology, Juntendo University, Tokyo, Japan.

Abstract

We tested the combined activity of vancomycin and seven beta-lactam antibiotics against Staphylococcus aureus clinical strain Mu3, which displays heterogeneous resistance to vancomycin. When combined with vancomycin, four of the seven tested beta-lactams exhibited an additive effect at or near their MICs, while all showed an antagonistic effect at lower, sub-MIC levels. This study implicated the unpredictable nature of combination therapy of beta-lactams and vancomycin against S. aureus with reduced susceptibility to vancomycin.

PMID:
11257050
PMCID:
PMC90459
DOI:
10.1128/AAC.45.4.1292-1294.2001
[Indexed for MEDLINE]
Free PMC Article

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