Matrix metalloproteinases of normal human tissues

Biochemistry (Mosc). 2001 Feb;66(2):130-40. doi: 10.1023/a:1002879128392.

Abstract

This review considers biochemical properties of the family of matrix metalloproteinases (MMPs) of normal human tissues and the involvement of these enzymes in morphogenesis. Four main MMP subfamilies are characterized, and a group of other MMPs is described. Data on mechanisms of activation and inhibition of MMPs in certain tissues during various physiological processes (embryogenesis, angiogenesis, tissue growth and involution) are considered. Information about tissue inhibitors of MMP is presented, and the ability of these inhibitors to regulate the activity of MMPs is analyzed.

Publication types

  • Review

MeSH terms

  • Humans
  • Matrix Metalloproteinases / classification
  • Matrix Metalloproteinases / metabolism*
  • Tissue Inhibitor of Metalloproteinases / metabolism

Substances

  • Tissue Inhibitor of Metalloproteinases
  • Matrix Metalloproteinases