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Biochimie. 2001 Jan;83(1):117-20.

Conserved sequence motif at the C-terminus of the bacterial cell-division protein FtsA.

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  • 1MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK. jyl@mrc-lmb.cam.ac.uk

Abstract

FtsA is an essential part of the septal ring structure in bacterial cell division. Two peptide-protein interactions are known in this process: FtsA and ZipA bind the C-terminus of FtsZ, the bacterial tubulin homologue, which is the first septal component to appear at the septum. Our recent crystal structure of FtsA revealed a possible peptide binding site on FtsA and a long disordered C-terminal region. Here we show that all FtsA proteins contain a conserved 10-13 residue motif at the C-terminal end that may facilitate targeting of downstream septal components.

PMID:
11254984
[PubMed - indexed for MEDLINE]
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