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Biochimie. 2001 Jan;83(1):19-23.

Escherichia coli DnaA protein--phospholipid interactions: in vitro and in vivo.

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1
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA. crooke@bc.georgetown.edu

Abstract

DNA replication in Escherichia coli is controlled at the initiation stage, possibly by regulation of the essential activity of DnaA protein. The cellular membrane has long been hypothesized to be involved in chromosomal replication. Accumulating evidence, both in vitro and in vivo, that supports the importance of membrane phospholipids influencing the initiation activity of DnaA is reviewed.

PMID:
11254970
[Indexed for MEDLINE]
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