Format

Send to

Choose Destination
Infect Immun. 2001 Apr;69(4):2708-13.

Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae.

Author information

1
The Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Ireland.

Abstract

Infection with Helicobacter pylori has been associated with induction of autoantibodies that cross-react with the gastric mucosa. There have been discordant reports as to whether or not these autoantibodies arise due to molecular mimicry between H. pylori and host cell antigens on parietal cells. In this study, we investigated whether molecular mimicry by H. mustelae causes autoantibodies in infected ferrets. Serum from H. mustelae-infected ferrets reacted with parietal cells in the ferret gastric mucosa but not with duodenal or colonic mucosa. These sera did not react with the blood group A epitope on erythrocytes or H. mustelae lipopolysaccharide, and absorption with H. mustelae whole cells or red blood cells did not remove autoantibodies. In conclusion, ferrets naturally infected with H. mustelae generate antibodies that react with parietal cells, but these autoantibodies are not due to molecular mimicry.

PMID:
11254638
PMCID:
PMC98210
DOI:
10.1128/IAI.69.4.2708-2713.2001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center