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Infect Immun. 2001 Apr;69(4):2700-7.

Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in buccal epithelial cells collected from human subjects.

Author information

  • 1Department of Oral Science and Minnesota Oral Health Clinical Research Center, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA. jrudney@tc.umn.edu

Abstract

The mouth may provide an accessible model for studying bacterial interactions with human cells in vivo. Using fluorescent in situ hybridization and laser scanning confocal microscopy, we found that human buccal epithelial cells from 23 of 24 subjects were infected with intracellular bacteria, including the periodontal pathogens Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, as well as other species which have yet to be identified. Buccal cell invasion may allow fastidious anaerobes to establish themselves in aerobic sites that otherwise present an unfavorable environment. Exfoliated buccal epithelial cells might provide a protected route for bacterial transmission between different oral sites within and between hosts.

PMID:
11254637
PMCID:
PMC98209
DOI:
10.1128/IAI.69.4.2700-2707.2001
[PubMed - indexed for MEDLINE]
Free PMC Article
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