Format

Send to

Choose Destination
Mol Gen Genet. 2001 Feb;264(6):782-9.

Essential genes in proximal 3L heterochromatin of Drosophila melanogaster.

Author information

1
Department of Molecular Biology and Biochemistry, Simon Fraser University Burnaby, BC, Canada.

Abstract

We have further characterized essential loci within the centric heterochromatin of the left arm of chromosome 3 (3L) of Drosophila melanogaster, using EMS, radiation and P element mutagenesis. We failed to find any new essential genes, a result that suggests a lower-than-average gene density in this region. Mutations affecting expression of the most proximal gene [lethal 1, l1 or l(3)80Fj] act as dominant suppressors of Polycomb (Pc), behavior which is consistent with a putative trithorax group (trx-G) gene. The third gene to the left of the centromere [lethal 3, l3 or l(3)80Fh] is likely to correspond to verthandi (vtd), a known trx-G gene that plays a role in the regulation of hedgehog (hh) expression and signalling. The intervening gene [lethal 2, l2 or l(3)80Fi] is required throughout development, and mutant alleles have interesting phenotypes; in various allelic combinations that survive, we observe fertility, bristle, wing, eye and cuticle defects.

PMID:
11254125
DOI:
10.1007/s004380000367
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center