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Nat Rev Mol Cell Biol. 2000 Dec;1(3):233-6.

Human cancer cell lines: fact and fantasy.

Author information

1
Institute of Urology, University College London, 67 Riding House Street, London W1W 7EY, UK. j.masters@ucl.ac.uk

Abstract

Cancer cell lines are used in many biomedical research laboratories. Why, then, are they often described as unrepresentative of the cells from which they were derived? Here, I argue that they have been unjustly accused. Under the right conditions, and with appropriate controls, properly authenticated cancer cell lines retain the properties of the cancers of origin.

PMID:
11252900
DOI:
10.1038/35043102
[Indexed for MEDLINE]

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