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Nat Rev Mol Cell Biol. 2000 Dec;1(3):217-24.

Intramembrane proteolysis by presenilins.

Author information

1
Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's Disease Research, Ludwig-Maximilians University, 80336 Munich, Germany.

Abstract

Many neurodegenerative diseases involve the deposition of insoluble amyloid molecules. In Alzheimer's disease, for example, the amyloid beta-peptide (A beta) is the main component of the characteristic senile plaques. Proteolytic enzymes called secretases are involved in generating A beta, and one of these may have been identified as presenilin--a discovery that paves the way for a more complete understanding of presenilin structure and function.

PMID:
11252897
DOI:
10.1038/35043065
[Indexed for MEDLINE]

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