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Nat Rev Mol Cell Biol. 2000 Dec;1(3):199-207.

P63 and P73: P53 mimics, menaces and more.

Author information

1
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA. fmckeon@hms.harvard.edu

Abstract

Inactivation of the tumour suppressor p53 is the most common defect in cancer cells. The discovery of its two close relatives, p63 and p73, was therefore both provocative and confounding. Were these new genes tumour suppressors, p53 regulators, or evolutionary spin-offs? Both oncogenic and tumour-suppressor properties have now been attributed to the p53 homologues, perhaps reflecting the complex, often contradictory, protein products encoded by these genes. p63 and p73 are further implicated in many p53-independent pathways, including stem-cell regeneration, neurogenesis and sensory processes.

PMID:
11252895
DOI:
10.1038/35043127
[Indexed for MEDLINE]

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