Abstract
As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Ataxia Telangiectasia / diagnosis
-
Ataxia Telangiectasia / genetics
-
Ataxia Telangiectasia Mutated Proteins
-
Cell Cycle
-
Cell Cycle Proteins
-
DNA Damage
-
DNA Repair
-
DNA-Binding Proteins
-
Humans
-
Models, Biological
-
Molecular Sequence Data
-
Phenotype
-
Protein Serine-Threonine Kinases / genetics
-
Protein Serine-Threonine Kinases / metabolism*
-
Protein Serine-Threonine Kinases / physiology*
-
Sequence Homology, Amino Acid
-
Tumor Suppressor Proteins
Substances
-
Cell Cycle Proteins
-
DNA-Binding Proteins
-
Tumor Suppressor Proteins
-
ATM protein, human
-
Ataxia Telangiectasia Mutated Proteins
-
Protein Serine-Threonine Kinases