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Nat Rev Neurosci. 2000 Oct;1(1):51-8.

Apolipoprotein E receptors: linking brain development and Alzheimer's disease.

Author information

1
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9046, USA. herz@utsw.swmed.edu

Abstract

Alzheimer's disease is a debilitating neurodegenerative disorder that afflicts an increasing part of our ageing population. An isoform of apolipoprotein E, a protein that mediates the transport of lipids and cholesterol in the circulatory system, predisposes carriers of this allele to the common late-onset form of the disease. How this protein is related to a neurodegenerative disorder is an enigma. Mounting evidence indicates that apolipoprotein E receptors, which are abundantly expressed in most neurons in the central nervous system, also fulfill critical functions during brain development and may profoundly influence the pathogenesis of Alzheimer's disease.

PMID:
11252768
DOI:
10.1038/35036221
[Indexed for MEDLINE]

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