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Nat Rev Genet. 2000 Dec;1(3):218-26. doi: 10.1038/35042080.

Using Drosophila as a model insect.

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Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.


The fruit fly Drosophila melanogaster has become such a popular model organism for studying human disease that it is often described as a little person with wings. This view has been strengthened with the sequencing of the Drosophila genome and the discovery that 60% of human disease genes have homologues in the fruit fly. In this review, I discuss the approach of using Drosophila not only as a model for metazoans in general but as a model insect in particular. Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development.

[Indexed for MEDLINE]

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