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Nat Rev Genet. 2000 Dec;1(3):171-81.

The establishment of Spemann's organizer and patterning of the vertebrate embryo.

Author information

1
Howard Hughes Medical Institute, and Department of Biological Chemistry, University of California, Los Angeles, California 90095-1662, USA. derobert@hhmi.ucla.edu

Abstract

Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.

PMID:
11252746
PMCID:
PMC2291143
DOI:
10.1038/35042039
[Indexed for MEDLINE]
Free PMC Article

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