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J Antimicrob Chemother. 1999 Feb;43(2):277-9.

Relationship between haemolysis production and resistance to fluoroquinolones among clinical isolates of Escherichia coli.

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Department of Microbiology, University Hospital Virgen Macarena, School of Medicine, Seville, Spain.

Erratum in

  • J Antimicrob Chemother 1999 Aug;44(2):307.


The activities of ampicillin, amoxycillin-clavulanic acid, gentamicin, tetracycline, nalidixic acid, ciprofloxacin, pefloxacin and trovafloxacin against 207 consecutive clinical isolates of Escherichia coli were determined. Fifty-six (27.3%) isolates were haemolytic. The percentages of resistance to quinolones and tetracycline, but not to other agents, among haemolytic isolates were significantly lower (P < 0.05) than among non-haemolytic isolates. Ciprofloxacin-resistant mutants obtained from ciprofloxacin-susceptible haemolytic isolates still produced haemolysis. It is concluded that most quinolone-resistant clinical isolates of E. coli are non-haemolytic, although haemolysis is produced by quinolone-resistant mutants derived from haemolytic quinolone-susceptible strains.

[Indexed for MEDLINE]

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