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Brain Res. 2001 Mar 16;894(2):274-80.

Anatomical sparing in the superior colliculus of hemispherectomized monkeys.

Author information

1
Groupe de Recherche en Neuropsychologie Expérimentale, Université de Montréal, CP 6128, PQ, H3C 3J7, Montréal, Canada. htheoret@caregroup.harvard.edu

Abstract

Using the monkey as a model for human hemispherectomy, the effects of early removal of a whole cerebral hemisphere on the cytoarchitecture and cytochrome oxidase histochemistry of the superior colliculus (SC) were evaluated. Results show that the SC ipsilateral to the cortical lesion suffers a 29.9% average volume reduction and a 32.7% total loss of neurons compared to the contralateral SC. Neuronal densities and metabolic activity are similar in normal and hemispherectomized monkeys. Furthermore, the ipsi- and contralesional SC receive retinal inputs as revealed with intraocular injections of tritiated proline. These data suggest that the superior colliculus retains functional capabilities following hemispherectomy in monkey.

PMID:
11251201
DOI:
10.1016/s0006-8993(01)02030-3
[Indexed for MEDLINE]

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