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Breast Cancer Res. 2000;2(6):417-22. Epub 2000 Aug 11.

Molecular biology of breast cancer metastasis. Molecular expression of vascular markers by aggressive breast cancer cells.

Author information

1
Department of Anatomy and Cell Biology, University of Iowa Cancer Center, Iowa City, Iowa, USA. mary-hendrix@uiowa.edu

Abstract

During embryogenesis, the formation of primary vascular networks occurs via the processes of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of aggressive, but not nonaggressive, tumor cells to form networks surrounding spheroids of tumor cells in three-dimensional culture; these recapitulate the patterned networks seen in patients' aggressive tumors and correlates with poor prognosis. The molecular profile of these aggressive tumor cells suggests that they have a deregulated genotype, capable of expressing vascular phenotypes. Similarly, the embryonic-like phenotype expressed by the aggressive human breast cancer cells is associated with their ability to express a variety of vascular markers. These studies may offer new insights for consideration in breast cancer diagnosis and therapeutic intervention strategies.

PMID:
11250735
PMCID:
PMC138664
[Indexed for MEDLINE]
Free PMC Article

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