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Breast Cancer Res. 2000;2(5):331-4. Epub 2000 Aug 4.

Nontransgenic models of breast cancer.

Author information

1
Breast Cancer Program, Karmanos Cancer Institute, 110 E. Warren Avenue, Detroit, MI 48201, USA. Heppnerg@karmanos.org

Abstract

Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and histopathology of human disease, and allow for basic investigations into underlying cellular and molecular mechanisms. We describe two types of models: those that are directed toward early events in breast cancer development (hyperplastic alveolar nodules [HAN] murine model, MCF10AT human xenograft model); and those that seek to reflect the spectrum of metastatic disease (murine sister cell lines 67, 168, 4T07, 4T1). Collectively, these models provide cell lines that represent all of the sequential stages of progression in breast disease, which can be modified to test the effect of genetic changes.

PMID:
11250725
PMCID:
PMC138654
DOI:
10.1186/bcr77
[Indexed for MEDLINE]
Free PMC Article

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