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Curr Opin Genet Dev. 2001 Apr;11(2):162-6.

Functional significance of histone deacetylase diversity.

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Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation - INSERM U309, Equipe, Grenoble, France.


Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuttling process is one of the distinctive characteristics of these enzymes, themselves belonging to structurally and functionally different classes. Considering the specific features of each class of deacetylases, it is possible to determine how each member can contribute to particular cellular functions.

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