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Curr Opin Genet Dev. 2001 Apr;11(2):155-61.

Histone acetyltransferases: function, structure, and catalysis.

Author information

1
Structural Biology Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA. marmor@wistar.upenn.edu

Abstract

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation.

PMID:
11250138
DOI:
10.1016/s0959-437x(00)00173-8
[Indexed for MEDLINE]

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