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Curr Opin Genet Dev. 2001 Apr;11(2):136-41.

The ins and outs of nucleosome assembly.

Author information

1
Institut Curie, Research section, UMR 218 du Centre National de la Recherche Scientifique (CNRS), 75248 Paris 05, Cedex, France. jill.mello@curie.fr

Abstract

De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-1). Recent studies support a model in which CAF-1 can be targeted to newly synthesized DNA through a direct interaction with proliferating cell nuclear antigen (PCNA) and can act synergistically with a newly identified histone chaperone. Insights have also been obtained into mechanisms by which this CAF-1-dependent pathway can establish a repressed chromatin state.

PMID:
11250135
DOI:
10.1016/s0959-437x(00)00170-2
[Indexed for MEDLINE]

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